Marburg Virus: Expert Q&A with Dr. Heinz Feldmann

What is Marburg virus disease?

Marburg virus disease (MVD) is a rare infectious disease caused by a filovirus known as Marburg virus.

The virus is transmitted to humans through contact with infected animals, such as fruit bats or nonhuman primates. It can also be transmitted through contact with the blood, bodily fluids, or tissues of an infected person.

What are the symptoms of Marburg virus disease?

The symptoms of MVD typically appear within 2-21 days after exposure to the virus.

Initial symptoms include fever, chills, headache, and muscle aches. These symptoms are often accompanied by nausea, vomiting, and diarrhea.

As the disease progresses, more severe symptoms may develop, including bleeding, organ failure, and shock.

How is Marburg virus disease diagnosed?

MVD is diagnosed through laboratory testing of blood or other bodily fluids. The virus can be detected using a variety of tests, such as an enzyme-linked immunosorbent assay (ELISA) or a polymerase chain reaction (PCR).

What is the treatment for Marburg virus disease?

There is no specific treatment for MVD. Treatment is supportive and focused on managing the symptoms of the disease.

Treatment may include fluids, electrolytes, and medications to relieve fever and pain. In some cases, blood transfusions or plasmapheresis may be necessary.

What is the prognosis for Marburg virus disease?

The prognosis for MVD depends on the severity of the disease. The case-fatality rate ranges from 24% to 88%.

Early diagnosis and treatment can improve the chances of survival.

How can Marburg virus disease be prevented?

There is no vaccine to prevent MVD.

Prevention measures focus on reducing exposure to the virus. These measures include avoiding contact with infected animals, practicing good hygiene, and using protective clothing when working with infected animals or their tissues.